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This photo shows a clear “win” from a phase 1 clinical trial of a new treatment for children who have already been heavily treated for neuroblastoma. The photo was published in a study in Nature Medicine with co-authors and American Cancer Society (ACS) research grantees Andras Heczey, MD, and Leonid Metelitsa, MD, PhD.
We’ve followed these studies at Baylor College of Medicine since Heczey received his first ACS research grant in 2016. That’s when he was genetically adapting CAR T-Cell therapy to treat neuroblastoma. Later, on a TheoryLab podcast, Heczey talked about his work with neuroblastoma (and with pediatric liver cancer). And, we reported on his progress when he initiated his experimental treatment’s first clinical trial.
These images are from updated interim phase 1 trial results published in Nature Medicine. At this phase, anti-tumor activity wasn’t the first goal, so it’s much too early to deem this new treatment a success. What researchers did conclude was: