Our 24/7 cancer helpline provides information and answers for people dealing with cancer. We can connect you with trained cancer information specialists who will answer questions about a cancer diagnosis and provide guidance and a compassionate ear.
Our highly trained specialists are available 24/7 via phone and on weekdays can assist through video calls and online chat. We connect patients, caregivers, and family members with essential services and resources at every step of their cancer journey. Ask us how you can get involved and support the fight against cancer. Some of the topics we can assist with include:
For medical questions, we encourage you to review our information with your doctor.
Grantee: Weiguo Cui, PhD
Institution: Medical College of Wisconsin in Milwaukee
Area of Study: Leukemia, Immunology, and Blood Cell Development
Grant Term: 1/1/18 to 12/31/21
The Challenge: Immunotherapy uses a patient’s own immune system to fight cancer. Certain types of immunotherapy known as cell therapy or cell transfer therapy, use immune cells called T cells, which are a type of white blood cell. The patient’s T cells are genetically changed in a lab to make them better able to kill cancer cells and returned to the patient’s body. But these superpowered T cells don’t work at full speed forever. They gradually become exhausted, and their cancer-killing abilities weaken.
The Research: Weiguo Cui, PhD, and his team on working on immunotherapy for melanoma. They believe they’ve found a genetic pathway that controls the T cells’ “killing” strength and duration. Using mice that have melanoma, Cui and his team are studying the pathway and hope to use it to design new ways to reprogram the exhausted T cells, thereby allowing them to regain and keep their “super-killing” abilities.
The Goal and Potential Long-Term Benefits: Cui’s team is hopeful that their work in mice will eventually lead to human studies to help develop new immunotherapy treatments that target different types of cancer cells.