The Cancer Prevention Study-3 (CPS-3) is a large, geographically and racially/ethnically diverse US cohort of 300,000 participants who were cancer free when they enrolled from 2006 to 2013 and who are continuing to be studied.
In December 2013, the American Cancer Society (ACS) launched Cancer Prevention Study-3 (CPS-3) when ACS completed its initial recruitment.
Who we invited: Our Cancer Prevention and Survivorship Team invited men and women between the ages of 30 and 65 who had no personal history of cancer to participate in the study.
Who we enrolled: The goal was to enroll at least 300,000 adults, and we enrolled approximately 303,500 from various racial and ethnic backgrounds from across the United States and Puerto Rico. The average age at enrollment was 47 years.
How we did it: The successful completion of this enrollment was possible because of the partnership of ACS staff and over 30,000 volunteers.
We enrolled participants at:
What it means to be a CPS-3 participant: All 300,000 participants enrolled in CPS-3 by completing a survey, and 99% of CPS-3 participants provided a blood sample at enrollment. Starting in 2015, every 3 years, we've sent out follow-up surveys to ask for both new and updated information, such as exposure to COVID-19 or changes in weight, diet, and physical activity. These triennial follow-up surveys also ask about recent cancer diagnoses and many other medical conditions and medications.
Why we collect biospecimens: Researchers use blood, urine, and stool samples to investigate genetic, epigenetic, and metabolomic markers associated with cancer or with cancer risk factors, and to better understand how those markers interact with various lifestyle and environment exposures. Many thousands of participants have agreed to take part in various CPS-3 sub-studies, providing urine, stool, or additional blood samples, as well as answering more specific surveys, wearing activity monitors, and more.
How long the study will last: The CPS-3 study will last 40 years. We mailed our first follow-up survey in 2015 and will continue to send one every 3 years until the year 2043. We sent out our latest follow-up survey in 2021.
How we keep improving: CPS-3 is committed to incorporating the latest technologies into every aspect of our research, including data collection and analysis, participant engagement, results delivery, and data security. We are in the process of expanding a CPS-3 Participant Portal, to improve communication with our participants and streamline the process of volunteering and participating in sub-studies like the Gut Microbiome sub-study.
Sub-Studies—smaller cohorts for more targeted research: In addition to the triennial follow-up surveys we send, we also invite CPS-3 participants to volunteer for sub-studies, which allow us to collect more detailed information about specific risk factors for cancer, such as physical activity.
Examples of some recent sub-studies: