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A risk factor is anything that increases your chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed.
In some cases, there might be a factor that may decrease your risk of developing cancer or has an unclear effect. That is not considered a risk factor, but you may see them noted clearly on this page as well.
Having a risk factor, or even many, does not mean that you will get cancer. And some people who get cancer may have few or no known risk factors.
Here are some of the risk factors known to increase your risk for pancreatic cancer.
Smoking is one of the most important risk factors for pancreatic cancer. The risk of getting pancreatic cancer is about twice as high among people who smoke compared to those who have never smoked. About 25% of pancreatic cancers are thought to be caused by cigarette smoking. Cigar smoking and the use of smokeless tobacco products also increase the risk. However, the risk of pancreatic cancer starts to drop once a person stops smoking . See Can Pancreatic Cancer Be Prevented?
Being very overweight (obese) is a risk factor for pancreatic cancer. Obese people (body mass index [BMI] of 30 or more) are about 20% more likely to develop pancreatic cancer. Gaining weight as an adult can also increase risk.
Carrying extra weight around the waistline may be a risk factor even in people who are not very overweight.
Pancreatic cancer is more common in people with diabetes. The reason for this is not known. Most of the risk is found in people with type 2 diabetes. This type of diabetes is increasing in children and adolescents as obesity in these age groups also rises. Type 2 diabetes in adults is also often related to being overweight or obese. It’s not clear if people with type 1 (juvenile) diabetes have a higher risk.
Chronic pancreatitis, a long-term inflammation of the pancreas, is linked with an increased risk of pancreatic cancer. Chronic pancreatitis is often seen with heavy alcohol use and smoking.
Heavy exposure at work to certain chemicals used in the dry cleaning and metal working industries may raise a person’s risk of pancreatic cancer.
The risk of developing pancreatic cancer goes up as people age. Almost all patients are older than 45. About two-thirds are at least 65 years old. The average age at the time of diagnosis is 70.
Men are slightly more likely to develop pancreatic cancer than women. This may be due, at least in part, to higher tobacco use in men, which raises pancreatic cancer risk (see above).
African Americans are slightly more likely to develop pancreatic cancer than whites. The reasons for this aren’t clear, but it may be due in part to having higher rates of some other risk factors for pancreatic cancer, such as diabetes, smoking , and being overweight.
Pancreatic cancer seems to run in some families. In some of these families, the high risk is due to an inherited syndrome (explained below). In other families, the gene causing the increased risk is not known. Although family history is a risk factor, most people who get pancreatic cancer do not have a family history of it.
Inherited gene changes (mutations) can be passed from parent to child. These gene changes may cause as many as 10% of pancreatic cancers. Sometimes these changes result in syndromes that include increased risks of other cancers (or other health problems). Examples of genetic syndromes that can cause pancreatic cancer include:
Changes in the genes that cause some of these syndromes can be found by genetic testing. For more information on genetic testing, see Can Pancreatic Cancer Be Found Early?
Chronic pancreatitis is sometimes due to an inherited gene mutation. People with this inherited (familial) form of pancreatitis have a high lifetime risk of pancreatic cancer.
Diets with red and processed meats (such as sausage and bacon) and saturated fats may increase the risk of pancreatic cancer. Sugary drinks may also increase this risk. More research is needed in this area.
Some research has suggested that lack of physical activity might increase pancreatic cancer risk. But not all studies have found this . Regular physical activity may help reduce the risk of pancreatic cancer.
Some older studies have suggested that drinking coffee might increase the risk of pancreatic cancer, but more recent studies have not confirmed this.
Some studies have shown a link between heavy alcohol use and pancreatic cancer. Heavy alcohol use can also lead to conditions such as chronic pancreatitis, which is known to increase pancreatic cancer risk.
Some research suggests that infection of the stomach with the ulcer-causing bacteria Helicobacter pylori (H. pylori) or infection with Hepatitis B may increase the risk of getting pancreatic cancer. More studies are needed.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
American Cancer Society. Cancer Facts & Figures 2013. Atlanta, Ga: American Cancer Society; 2013.
American Cancer Society. Cancer Facts & Figures 2018. Atlanta, Ga: American Cancer Society; 2018.
Beavers TB, Brown PH, Maresso KC, Hawk ET. Chapter 23: Cancer Prevention, Screening, and Early Detection. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 5th ed. Philadelphia, Pa. Elsevier: 2014.
Canto MI. Familial risk factors for pancreatic cancer and screening of high-risk patients. UpToDate website. https://www.uptodate.com/contents/familial-risk-factors-for-pancreatic-cancer-and-screening-of-high-risk-patients. Updated Nov 2, 2018. Accessed January 2, 2019.
Fernandez-del Castillo C and Jimenez RE. Epidemiology and nonfamilial risk factors for exocrine pancreatic cancer. UpToDate website. https://www.uptodate.com/contents/epidemiology-and-nonfamilial-risk-factors-for-exocrine-pancreatic-cancer. Updated May 14, 2018. Accessed December 19, 2018.
Lucenteforte E, La Vecchia C, Silverman D, et al. Alcohol consumption and pancreatic cancer: A pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2012;23:374−382.
Jesus-Acosta AD, Narang A, Mauro L, Herman J, Jaffee EM, Laheru DA. Chapter 78: Carcinoma of the pancreas. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa. Elsevier: 2020.
Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2015, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2015/, based on November 2017 SEER data submission, posted to the SEER web site, April 2018.
Rock CL, Thomson C, Gansler T, et al. American Cancer Society guideline for diet and physical activity for cancer prevention. CA: A Cancer Journal for Clinicians. 2020;70(4). doi:10.3322/caac.21591. Accessed at https://onlinelibrary.wiley.com/doi/full/10.3322/caac.21591 on June 9, 2020.
Winter JM, Brody JR, Abrams RA, Posey JA, Yeo CJ. Chapter 55: Cancer of the Pancreas. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019.
Last Revised: June 9, 2020
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